Thermal energy sources such as laser ablation (LA) or radiofrequency ablation (RFA) make the destruction of  benign thyroid nodules possible without surgical removal. The potential advantages of in situ tumor ablation include decreased costs, reduced morbidity, the possibility of performing procedures on outpatients, and the possibility of treating patients who are poor candidates for surgery because of age, comorbidity, or extent of disease. The main disadvantages of in situ ablation procedures, instead, concern the difficulty of evaluating the extent of disease and, rarely, of the irreversible tissue damage induced by image-guided thermal ablation.

Indications and Limitations


Currently available ultrasound-guided minimally invasive procedures can induce a rapid, clinically significant long-term size reduction of benign thyroid nodules with  minimal risks. Ethanol injection should preferentially be considered as the  first-line treatment for relapsing thyroid cysts. The thermo-ablative techniques, instead, may be used as an alternative to surgery in patients with solid or partially cystic benign thyroid nodules causing aesthetic problems or compressive  symptoms, achieving a significant volume reduction. Less appropriate  indications are large nodular goiters, multinodular thyroid disease, or deeply positioned lesions.

Dr. Roberto Valcavi

Endocrinologia - Malattie della Tiroide

P. IVA 02641010356

Centro Palmer Srl

Via Fratelli Cervi, 75/b

42124 Reggio Emilia RE, Italy


Roberto Valcavi
Centro Palmer


+39 0522 792400

+39 0522 307856

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